منابع مشابه
Getting In and Out of Mitosis*
A series of preparatory steps must take place before a cell enters mitosis, and these steps must be undone to exit mitosis. The cell has a nucleus which contains the genetic material, the DNA, as chromosomes packaged with proteins. Before the cell undergoes mitosis, the cell must make two copies of its DNA so that each daughter cell has a complete copy of the genetic material. At the onset of m...
متن کاملProgression into and out of mitosis.
Progression through mitosis is controlled by cyclin-dependent kinases, which drive cells into metaphase, and by the anaphase-promoting complex/cyclosome, a ubiquitin ligase that triggers sister chromatid separation and exit from mitosis. Recent work has shown how the mutual regulation between cyclin-dependent kinases and the anaphase-promoting complex/cyclosome ensures that cell-cycle events oc...
متن کاملCell Cycle: Stressed Out of Mitosis
Cells in early stages of chromosome condensation are very vulnerable, and many stresses that do not damage DNA induce a transient return to late G2 phase. Such stresses include the drug-induced disassembly of microtubules, which triggers an ATM-independent G2 checkpoint pathway involving a novel ubiquitin ligase.
متن کاملCell Cycle: The only way out of mitosis
The ubiquitination and destruction of cyclins provides the way out of mitosis. A multiprotein complex polyubiquitinates cyclin B and promotes the separation of sister chromatids.
متن کاملMitosis sans Mitosis: The Mitotic Oscillator in Differentiation.
Differentiation and proliferation are usually considered to be antagonistic partners in development. However, in a recent issue of Science, Al Jord et al. (2017) show that key regulators of the mitotic cycle are redeployed in differentiating multiciliated cells to promote ciliogenesis without mitotic progression.
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2003
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.2.3.405